CARE-ME® delivers currents known as TENS (Transcutaneous Neurostimulation) which have been known for many years (Wall and Sweet 1967) for their painkilling effect, and specific currents to produce curative effects against the central neurochemical causes of migraines.

These currents act:

Palliatively by:

  • Blocking the transmission of nerve impulses in the sensory nerves.
  • Blocking nervous transmission of pain in the spinal cord (Melzack and Wall 1965).

Curatively by:

  • Stimulating certain brain circuits whose function is to produce endorphins (natural painkilling substances).
  • Stimulating brain circuits which inhibit pain transmission using serotonin in particular.
  • Modifying the release of serotonin by the nerve endings of the trigeminal nerve which are responsible for the initial vasoconstriction followed by the subsequent vasodilation of the meningeal vessels, which in turn are responsible for migraine pain.
  • Long-term modification of the expression of the genes responsible for serotonin synthesis in certain neurons.

CARE-ME® has been specifically studied, and uses a special current that acts on the central nervous system by decreasing the influence of serotonin, which is known to be responsible for migraine pain through its effect of dilating the blood vessels of the skull base and the meninges.

For these reasons, the currents produced by CARE-ME® excite the fibres of the trigeminal nerve, which is responsible for the distribution of pain to the face and head (Trigeminovascular Theory).